CORNELIUS F. IVORY
Dept. Chemical Engineering
B43 EE/ME Building
Washington State University
P.O. Box 642710
Pullman, WA 99l64-27l0

Office: (509) 335-7716
FAX: (509) 335-4806
e-mail: cfivory at wsu dot edu
Microchip ITP Link
1987 Science Cover
EDUCATION.
1980 Princeton University, Ph.D. Chemical Engng
1976 Princeton University, Master of Arts in Chemical Engng
1974 University of Notre Dame, B.S. Chemical Engng

PROFESSIONAL EXPERIENCE.
Distinguished User, Molecular Foundry, Lawrence-Berkeley National Lab, 09/06 - present
Councilor, American Electrophoresis Society, 10/05 - present
Senior Fellow, Biomedical Engineering Center, U. New Mexico, 05/05 - present
Associate Director, NIH Predoctoral Program in Biotechnology 9/01 - present
Sabbatical Leave at University of Delaware, 9-12/03
Washington State University 1989-present

CURRENT COURSES.
ChE 334: Chemical Engineering Separations
ChE 433: Undergraduate Unit Operations Lab
ChE 435: Modern Separation Processes
ChE 475: Introduction to Biochemical Engineering
ChE 541: Chemical Engineering Analysis.
ChE 574: Protein Biotechnology
ChE 561: Downstream Processing
ChE 596: Research Methods I.
ChE 597: Research Methods II
ChE 598: Research Seminar

RESEARCH AREAS.
Biological Separations: Electrophoresis and Electrochromatography
Protein Transport in Ion Exchange Resins: Ann-Marie Hardin
Dynamic Field Gradient Focusing: Jeff Burke
Fast Preparative Isoelectric Focusing: Danny Bottenus
Preparative Field-Gradient Focusing: Noah Tracy
Micropreparative Purification of Protein Isoforms:
Isotachophoresis (ITP)
Membrane Separations: Electro-Ultrafiltration
Process Stability: Hydrodynamic and electrical instabilities
The NIH Biotech Program is open to ChEs for graduate training.
PROFESSIONAL RECOGNITION.
Program Co-Chair, American Electrophoresis Society, CEPharm Meeting, Jersey City, 10/06
Outstanding Researcher, School of Chemical Engineering and Bioengineering
Program Co-Chair, American Electrophoresis Society, 11/03 National Meeting in San Francisco
Associate Director, NIH Predoctoral Program in Biotechnology 9/01 - present
Editorial Board, Separation Science and Technology, 1997-present
Outstanding Teacher Award, WSU Department of Chemical Engineering, 1990
Editorial Advisory Board, Industrial and Engineering Chemistry Research, 1990
Special Issue Editor, Separation Science and Technology, 1988
National Program Committee Chair, Industrial & Engng. Chem. Div., ACS, 1987-1990.

BOOK CHAPTERS (Since 1999).
Alternative Focusing Techniques, Ivory, C. F., in the Handbook of Isoelectric Focusing and Proteomics, S. Ahuja and D. Garfin, eds., CRC Press 2005

Chapter 9: "Electrophoresis of Proteins: Batch and Continuous Methods, in
The Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparations,
M. Flickinger and S. Drew, eds., John Wiley and Sons, Inc. 1999

RECENT PUBLICATIONS. (Full Curriculum Vitae PDF)
Burke, J.M. and C. F. Ivory, “Characterization of voltage degradation in dynamic field gradient focusing,” Electrophoresis, 29(5):1013-25 (2008)

Shim J., P. Dutta and C. F. Ivory, “Effects of ampholyte concentration on protein behavior in on-chip isoelectric focusing,” Electrophoresis, 29(5):1026-35 (2008).

Shim, J. and Dutta, P., and Ivory, C. F., “Effects of Dissociation Constants on protein Separation in on-Chip Isoelectric Focusing,” Journal of Nanoscience and Nanotechnology (2008) In Press

Tracy, N.I., Z. Huang and C. F. Ivory, “Design and construction of a preparative-scale dynamic field gradient focusing apparatus,” Biotechnol Prog., 24(2):444-51 (2008).

Oh Y.J., T. C. Gamble, D. Leonhardt, C. H. Chung, S. R. Brueck, C. F. Ivory, G. P. Lopez, D. N. Petsev, and S. M. Han, “Monitoring FET flow control and wall adsorption of charged fluorescent dye molecules in nanochannels integrated into a multiple internal reflection infrared waveguide,” Lab Chip 8(2):251-8 (2008).

Tracy N. I. and C. F. Ivory, “Assessing the scalability of dynamic field gradient focusing by linear modeling,” J Sep Sci. 31(2):341-52 (2008).

Tuñón, P. G., Wang, Y., Myers, P., Bartle, K.D., Bowhill, L., Ivory, C.F., Ansell, R.J., "Electrophoretic field gradient focusing: An investigation of the experimental parameters," Electrophoresis, 29(2):457-65 (2008)

Horiuchi K., P. Dutta and C. F. Ivory, “Electroosmosis with Step Changes in Zeta Potential in Microchannel Electrophoresis,” AIChE J., 53(10) 2521-2533 (2007).

Harrison, S. and C. F. Ivory, “An Analytical Expression which Predicts the Location of Stationary, Steady-State Zone Positions in Isotachophoresis,” J. Separation Science, 30(18):3255-61 (2007).

Shim, J., P. Dutta, and C. F. Ivory, "Finite-volume methods for isotachophoretic separation in microchannels." Numerical Heat Transfer Part a-Applications 52(5): 441-461 (2007).

Thome, B. and C. F. Ivory, “True moving bed electrophoresis using stepped electric field gradients,” Electrophoresis, 28(10):1477-1487 (2007).

Cui, H., N. H., P. Dutta and C. F. Ivory, “Isotachophoresis of Proteins in a Microfluidic chip with T-Junctions: Experiment and 2D Simulation,” Electrophoresis, (7):1138-45 (2007).

Ivory, C. F., Several New Electrofocusing Techniques, Electrophoresis, (1-2):15-25 (2007).

Cui, H., N. H., Z. Huang, P. Dutta and C. F. Ivory, “Dynamic Electric Valving for Electrokinetic Separation in a Networked Microfluidic Chip,” Anal. Chem., 79(4):1456-65 (2007).

Thome, B. and C. F. Ivory, “Increasing the Scale of True Moving Bed electrophoretic separations using filtration to reduce solvent volumetric flows between sections II and III,” J. Chromatogr. 1138(1-2) 291-300 (2007).

Shim J-S., P. Dutta and C. F. Ivory, “Modeling and Simulation of Isoelectric Focusing in Two-Dimensional Geometries,” Electrophoresis. 28(4):572-86 (2007)

Hardin, A. M. and C. F. Ivory, “Buffer salt effect on pH in the interior of an anion exchange resin,” J. Colloid Interface Sci., 302(2) 560-7 (2006).

Thome, B. and C. F. Ivory, “Continuous Voltage Gradients and Their Application to True Moving Bed Electrophoresis,” J. Chromatogr. 1129(1) 119-28 (2006).

Bottenus D., and C. F. Ivory, “Effects of Increased Voltage on Resolution in Isoelectric Focusing of Myoglobin Variants,” Electrophoresis. 27(17) 3325-31 (2006).

Bottenus, D. and C. F. Ivory, “On-Line Optical Fiber Detection in a Preparative Vortex-Stabilized Free-Flow Electrofocusing Apparatus,” Biotechnology Progress 22(3) 842-846 (2006).

Cui, H., K. Horiuchi, P. Dutta and C. F. Ivory, “Multistage isoelectric focusing in a Poly(dimethylsiloxane) microfluidic chip,” Analytical Chemistry 77(24) 7878-86 (2005).

Petsev, D. N., G. P. Lopez, C. F. Ivory, S. S. Sibbett, “Microchip Protein Separation by Electric Field Gradient Focusing,” Lab-on-a-Chip, 5(6) 587-597 (2005).

Cui, H., K. Horiuchi, P. Dutta and C. F. Ivory, “Isoelectric focusing in a Poly(dimethylsiloxane) microfluidic chip,” Analytical Chemistry 77(5):1303-9 (2005).

Ivory, C. F., “Preparative Free-Flow Electrofocusing in a Vortex-Stabilized Annulus,” Electrophoresis, 25 360-374 (2004).

Ross, D., C. F. Ivory, L. E. Locascio, and K. E. Van Cott, “Peak Compression and Resolution for Electrophoretic Separations in Diverging Microchannels,” Electrophoresis, 25(21-22) 3694-3704 (2004).

Tracy, N. and C. F. Ivory, “Modeling Two-Component Isoelectric Focusing Buffers in a Vortex-Stabilized Electrophoresis Apparatus,” Biotechnol. Progress 20(1) 193-199 (2004).

Tracy, N. and C. F. Ivory, “Preparative Focusing of Proteins Using Binary Buffers in a Vortex-Stabilized, Free-Flow Apparatus,” Electrophoresis 25(12) 1748-1757 (2004).

Ista, L. K., G. P. Lopez, C. F. Ivory, M. J. Ortiz, T. A. Schifani, C. D. Schwappach, and S. S. Sibbett, “Microchip Countercurrent Electroseparation,” Lab-on-a-Chip, 3(4) 266-272 (2003).

Thome, B. and C. F. Ivory, “Development of a Segmented Model for a Continuous Electrophoretic Moving Bed Enantiomer Separation,” Biotechnol. Progr., 19(6) 1703-12 (2003)